Endocrine Abstracts

Background: Human toxicity of bisphenol-A (BPA), a weak estrogenic environmental endocrine disruptor widely used in plastics, babybottles, cans and dental sealants, is under investigation. Human pharmacokinetics involves a rapid inactivation by hepatic glucuronyl- or sulfoconjugation and renal clearance. Fetal or perinatal exposure in rodents is associated with programmed adult reproductive diseases. Human epidemiological studies remain scarce especially concerning testicular ...